Histaminergic modulation in Tourette syndrome
نویسندگان
چکیده
Heart of England NHS Foundation Trust, Birmingham, UK School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK Children’s Epilepsy Surgery Programme, The Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK Department of Neuropsychiatry, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and UCL, London, UK
منابع مشابه
Co-Morbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome in Child Referral Psychiatry Clinic in Iran
Objectives: Tourette syndrome is a disorder with motor and vocal tics, which has many psychiatric comorbidities. Attention Deficit Hyperactivity Disorder (ADHD) is one of co-morbid features of this syndrome. The aim of this research is studying Tourette and co morbidity ADHD in school age children. One of our purposes is to identify the range of ADHD in Iranian Tourette patients. Methods: Th...
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The neuromodulator histamine is released throughout the brain during periods of wakefulness. Combined with an abundant expression of histamine receptors, this suggests potential widespread histaminergic control of neural circuit activity. However, the effect of histamine on many of these circuits is unknown. In this review we will discuss recent evidence for histaminergic modulation of the basa...
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Support of the histaminergic hypothesis in Tourette Syndrome: association of the histamine decarboxylase gene in a large sample of families Iordanis Karagiannidis, Sandra Dehning, Paul Sandor, Zsanett Tarnok, Renata Rizzo, Tomasz Wolanczyk, Marcos Madruga-Garrido, Johannes Hebebrand, Markus M Nöthen, Gerd Lehmkuhl, Luca Farkas, Peter Nagy, Urszula Szymanska, Zachos Anastasiou, Vasileios Stathia...
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Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Hdc knockout mice exhibit repetitive behavioral pathology and neurochemical characteristics of TS, establishing them as a plausible model of tic pathophysiology. Wher...
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Objectives: Tourette syndrome is a disease with vocal and motor tics. This disorder is co-morbid with many psychiatric disorders, among which obsessive-compulsive disorder is the most common. Methods: During a one-year period, 30 patients with Tourette disorder were studied at an adolescent psychiatry referral clinic. It was an analytical-descriptive study. Subjects were selected by convenie...
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